Publikationen

2016

Beitzen-Heineke A, Bouzani M, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Loeffler J (2016) Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. Med Mycol 54(2), 169-176.

Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O (2016) Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1. Cellular Microbiology 18(7), 889-904.

Brandes S, Dietrich S, Hünniger K, Kurzai O, Figge MT (2016) Migration and Interaction Tracking for Quantitative Analysis of Phagocyte-Pathogen Confrontation Assays. Medical Image Analysis. 36, 172-183.

Czakai K, Leonhardt I, Dix A, Bonin M, Linde J, Einsele H, Kurzai O, Löffler J (2016) Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans Sci Rep 6, 27990.

Fliesser M, Wallstein M, Kurzai O, Einsele H, Löffler J (2016) Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells. Mycoses 59(8), 503-508.

Hellwig D, Voigt J, Bouzani M, Löffler J, Albrecht-Eckardt D, Weber M, Brunke S, Martin R, Kurzai O, Hünniger K (2016) Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a Zinc depletion response. Front Microbiol 7, 750.

Hube B, Kurzai O (2016) Text book chapter in: Clinical Mycology at Oxford University Press. Chapter: Candida. In: Clinical Mycology Oxford University Press.

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68.

Voigt K, Wolf T, Ochsenreiter K, Nagy G, Kaerger K, Shelest E, Papp T (2016) Text book chapter in: The Mycota Vol. III: Biochemistry and Molecular Biology. 3rd edition. Chapter: Genetic and metabolic aspects of primary and secondary metabolism of the Zygomycetes. In: Springer Verlag.

 

2015

Kaerger K, Schwartze VU, Dolatabadi S, Nyilasi I, Kovács SA, Binder U, Papp T, Hoog Sd, Jacobsen ID, Voigt K. Adaptation to thermotolerance in Rhizopus coincides with virulence as revealed by avian and invertebrate infection models, phylogeny, physiological and metabolic flexibility. Virulence. 2015;6(4):395-403.

Lehnert T, Timme S, Pollmächer J, Hünniger K, Kurzai O, Figge MT. Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Front Microbiol. 2015 Jun 19;6:608.

Münchberg U, Wagner L, Rohrer C, Voigt K, Rösch P, Jahreis G, Popp J. Quantitative assessment of the degree of lipid unsaturation in intact Mortierella by Raman microspectroscopy. Anal Bioanal Chem. 2015 May;407(12):3303-11.

Duggan S, Essig F, Hünniger K], Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O. Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol. 2015 Apr 7. E-pub ahead of print.

Dix A, Hünniger K, Weber M, Guthke R, Kurzai O, Linde J. Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study. Front Microbiol. 2015 Mar 11;6:171.

Duggan S, Leonhardt I, Hünniger K, Kurzai O. Host response to Candida albicans bloodstream infection and sepsis. Virulence. 2015 May 19;6(4):316-26.

Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Bläss M, Claus R, Barz D, Scherlach K, Hertweck C, Löffler J, Hünniger K, Kurzai O. The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio 2015 Mar 17;6(2):e00143.

Brandes S, Mokhtari Z, Essig F, Hünniger K, Kurzai O, Figge MT. Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Med Image Anal. 2015 Feb;20(1):34-51.

Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, Kurzai O. Defining the transcriptomic landscape of Candida glabrata by RNA-Seq. Nucleic Acids Res. 2015 Feb 18;43(3):1392-406.

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo RF, Riedemann NC, Kurzai O. A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin c5a. J Immunol. 2015 Feb 1;194(3):1199-210.

2014

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B. Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLoS Genet. 2014 Dec 4;10(12):e1004824.

Schwartze VU, Santiago AL, Jacobsen ID, Voigt K. 14. The pathogenic potential of the Lichtheimia genus revisited: Lichtheimia brasiliensis is a novel, non-pathogenic species. Mycoses. 2014 Dec;57 Suppl 3:128-31.

Park HR, Voigt K. Interaction of Zygomycetes with innate immune cells reconsidered with respect to ecology, morphology, evolution and infection biology: a mini-review. Mycoses. 2014 Dec;57 Suppl 3:31-9.

El-Shabrawi MH, Kamal NM, Kaerger K, Voigt K. Diagnosis of gastrointestinal basidiobolomycosis: a mini-review. Mycoses. 2014 Dec;57 Suppl 3:138-43.

Kraibooj K, Park HR, Dahse HM, Skerka C, Voigt K, Figge MT. Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses. 2014 Dec;57 Suppl 3:56-66.

de Hoog S, Ibrahim AS, Voigt K. Zygomycetes: an emerging problem in the clinical laboratory. Mycoses. 2014 Dec;57 Suppl 3:1.

Cunha C, Kurzai O, Löffler J, Aversa F, Romani L, Carvalho A. Neutrophil Responses to Aspergillosis: New Roles for Old Players. Mycopathologia. 2014 Dec;178(5-6):387-93.

Mendoza L, Vilela R, Voelz K, Ibrahim AS, Voigt K, Lee SC. Human fungal pathogens of mucorales and entomophthorales. Cold Spring Harb Perspect Med. 2014 Nov 6;5(4).

Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J. Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.
Int J Med Microbiol. 2014 Nov;304(8):1160-8.

Jacobsen ID, Lüttich A, Kurzai O, Hube B, Brock M. In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother. 2014 Oct;69(10):2785-96.

Linde J, Schwartze V, Binder U, Lass-Flörl C, Voigt K, Horn F. De Novo Whole-Genome Sequence and Genome Annotation of Lichtheimia ramosa. Genome Announc. 2014 Sep 11;2(5).

Ekaney M, Otto G, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M, Claus R. Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care. 2014 Sep 24;18(5):543.

Schwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M, Brakhage AA, Gabaldón T, Böcker S, Voigt K. Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina). PLoS Genet. 2014 Aug 14;10(8):e1004496.

Quintin J, Voigt J, Voort RV, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, Meer JW, Joosten LA, Kurzai O, Netea MG. Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol. 2014 Aug;44(8):2405-14.

Das Gupta M, Fliesser M, Springer J, Breitschopf T, Schlossnagel H, Schmitt AL, Kurzai O, Hünniger K, Einsele H, Löffler J. Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells. Int J Med Microbiol. 2014 Jul;304(5-6):592-6.

Cunha C, Kurzai O, Carvalho A. PTX3 deficiency and aspergillosis. N Engl J Med. 2014 Apr 24;370(17):1666-7.

Miramón P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B. A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol2014 Apr;52(3):223-39.

Hünniger K, Lehnert T, Bieber K, Martin R, Figge MT, Kurzai O. A virtual infection model quantifies effector mechanisms and Candida albicans Immune escape in human blood. PLoS Comput Biol. 2014 Feb 20;10(2):e1003479.

Hentschel J, Müller U, Doht F, Fischer N, Böer K, Sonnemann J, Hipler C, Hünniger K, Kurzai O, Markert UR, Mainz JG. Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers - Evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases. J Immunol Methods. 2014 Feb;404:41-51.

Voigt J, Hünniger K, Bouzani M, Jacobsen I, Barz D, Hube B, Löffler J, Kurzai O. Phagocytosis of Candida albicans by human NK Cells results in a proinflammatory response. Journal of Infectious Diseases. J Infect Dis. 2014 Feb; 209(4):616-26.

Grützmann K, Szafranski K, Pohl M, Voigt K, Petzold A, Schuster S. Fungal alternative splicing is associated with multicellular complexity and virulence: a genome-wide multi-species study. DNA Res. 2014 Feb;21(1):27-39.

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O Grube M, Löffler J, Maertens J, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A. Genetic deficiency of PTX3 and invasive aspergillosis in stem cell transplantation, accepted for publication. N Engl J Med. 2014 Jan 30; 370(5):421-32.

Grützmann K, Szafranski K, Pohl M, Voigt K, Petzold A, Schuster S. Fungal alternative splicing is associated with multicellular complexity and virulence - A genome-wide multi-species study. DNA Res. 2014;21(1):27-39.

2013

Luo S, Skerka C, Kurzai O, Zipfel PF. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol. 2013 Dec 15;56(3):161-9.

Sahadevan Y, Richter-Fecken M, Kaerger K, Voigt K, Boland W. Early and late trisporoids differentially regulate β-carotene production and gene transcript Levels in the mucoralean fungi Blakeslea trispora and Mucor mucedo. Appl Environ Microbiol. 2013 Dec;79(23):7466-75.

Schwab KS, Hahn-Ast C, Heinz WJ, Germing U, Egerer G, Glasmacher A, Leyendecker C,  Marklein G, Nellessen CM, Brossart P, von Lilienfeld-Toal M. Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals. Infection. 2013 Aug 25. [Epub  ahead  of  print]  PubMed  PMID: 23979853.

Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, Ferrara F, Fazi P, Cicconi L, Di Bona E, Specchia G, Sica S, Divona M, Levis A, Fiedler W, Cerqui E, Breccia M, Fioritoni G, Salih HR, Cazzola M, Melillo L, Carella AM, Brandts CH, Morra E, von Lilienfeld-Toal M, Hertenstein B, Wattad M, Lübbert M, Hänel M, Schmitz N, Link H, Kropp MG, Rambaldi A, La Nasa G, Luppi M, Ciceri F, Finizio O, Venditti A, Fabbiano F, Döhner K, Sauer M, Ganser A, Amadori S, Mandelli F, Döhner H, Ehninger G, Schlenk RF, Platzbecker U; Gruppo Italiano Malattie Ematologiche dell'Adulto; German-Austrian Acute  Myeloid  Leukemia Study Group; Study Alliance Leukemia. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013 Jul 11;369(2):111-21. 

Voigt K, Vaas L, Stielow B, de Hoog GS. The zygomycetes in a phylogenetic perspective. Persoonia 2013 Jun; 30: i–iv

Gryganskyi AP, Humber RA, Smith ME, Hodge K, Huang B, K. Voigt K, Vilgalys R Phylogenetic lineages in Entomophthoromycota. Persoonia. 2013 Jun; 30:94-105.

Wagner L, Stielow B, Hoffmann K, Petkovits T, Papp T, Vágvölgyi C, de Hoog GS, Verkley G, Voigt K. A comprehensive molecular phylogeny of the Mortierellales (Mortierellomycotina) based on nuclear ribosomal DNA. Persoonia. 2013 Jun; 30:77-93.

Hoffmann K, Pawlowska J, Walther G, Wrzosek M, de Hoog GS, Benny GL, Kirk PM, Voigt K. The family structure of the Mucorales: a synoptic revision based on comprehensive multigene-genealogies. Persoonia. 2013 Jun; 30: 57–76

Gaidzik VI, Schlenk RF, Paschka P, Stölzle A, Späth D, Kuendgen A, von Lilienfeld-Toal M, Brugger W, Derigs HG, Kremers S, Greil R, Raghavachar A, Ringhoffer M, Salih HR, Wattad M, Kirchen HG, Runde V, Heil G, Petzer AL, Girschikofsky M, Heuser M, Kayser S, Goehring G, Teleanu MV, Schlegelberger B, Ganser A, Krauter J, Bullinger L, Döhner H, Döhner K. Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood. 2013 Jun 6;121(23):4769-77.

Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hünniger K, Kurzai O. A core filamentation response network in Candida albicans is restricted to eight genes. PLoS One. 2013;8(3):e58613.

Cottier F, Leewattanapasuk W, Kemp LR, Murphy M, Supuran CT, Kurzai O, Mühlschlegel FA. Carbonic anhydrase regulation and CO2 sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog. Bioorg Med Chem. 2013 Mar 15; 21(6):1549-54.

Münchberg U, Wagner L, Spielberg ET, Voigt K, Rösch P, Popp J. Spatially resolved investigation of the oil composition in  ingle intact hyphae of Mortierella spp. with micro-Raman spectroscopy. Biochim Biophys Acta 2013 Feb;1831(2):341-9.

Paschka P, Du J, Schlenk RF, Gaidzik VI, Bullinger L, Corbacioglu A, Späth D, Kayser S, Schlegelberger B, Krauter J, Ganser A, Köhne CH, Held G, von  Lilienfeld-Toal M, Kirchen H, Rummel M, Götze K, Horst HA, Ringhoffer M, Lübbert M, Wattad M, Salih HR, Kündgen A, Döhner H, Döhner K. Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). Blood. 2013 Jan 3;121(1):170-7.

2012

Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B. (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLoS One. 2012; 7(12):e52850.

Schwartze VU, Hoffmann K, Nyilasi I, Papp T, Vágvölgyi C, de Hoog S, Voigt K, Jacobsen ID. Lichtheimia species exhibit differences in virulence potential. PLoS One. 2012;7(7):e40908.

Gryganskyi A, Humber RA, Smith ME, Miadlikovska J, Wu S, Voigt K, Walther G, Anishchenko IM, Vilgalys R. Molecular Phylogeny of the Entomophthoromycota. Molecular Phylogenetics & Evolution 2012 Nov;65(2):682-94.

Fleischhacker M, Schulz S, Jöhrens K, von Lilienfeld-Toal M, Held T, Fietze E, Schewe C, Petersen I, Ruhnke M. Diagnosis of chronic disseminated candidosis from liver biopsies by a novel PCR in patients with haematological malignancies. Clin  Microbiol Infect. 2012 Oct;18(10):1010-6. 

Escalante-Pérez  M,  Jaborsky  M,  Reinders  J,  Kurzai  O,  Hedrich  R,  Ache  P.  Poplar Extrafloral Nectar Is Protected against Plant and Human Pathogenic Fungus. Mol Plant. 2012 Sep; 5(5):1157-9.

Martínez-Ramírez JA, Voigt K, Peters FT. Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis. Analytical and Bioanalytical Chemistry 2012 Sep;404(5):1339-59.

Bauer R, Mezger M, Blockhaus C, Schmitt AL, Kurzai O, Einsele H, Loeffler J. 40-O -[2-Hydroxyethyl]rapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus. J Basic Microbiol. 2012 Jun; 52(3):269-76.

Heddergott C, Bruns S, Nietzsche S, Leonhardt I, Kurzai O, Kniemeyer O, Brakhage AA. The  Arthroderma benhamiae  hydrophobin  HypA  mediates  hydrophobicity  and  influences recognition by human immune effector cells. Eukaryot Cell. 2012 May; 11(5):673-82.

Ebersberger I, de Matos Simoes R, Kupczok A, Gube M, Kothe E, Voigt K, von Haeseler A. A consistent phylogenetic backbone for the fungi. Molecular Biology & Evolution 2012 May;29(5):1319-34

Gaidzik VI, Paschka P, Späth D, Habdank M, Köhne CH, Germing U, von Lilienfeld-Toal M, Held G, Horst HA, Haase D, Bentz M, Götze K, Döhner H, Schlenk RF, Bullinger L, Döhner K. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J Clin Oncol. 2012 Apr 20;30(12):1350-7.

Schoch CL, Seifert KA, Huhndorf S, Robert V, Spouge JL, Levesque CA, Chen W, Bolchacova E, Voigt K and the Fungal Barcoding Consortium. Nuclear  ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi. Proc Natl Acad Sci U. S. A. 2012 Apr 17;109(16):6241-6.

Kurzai O, Gow N. A case for case reports-And a new publishing platform for clinical mycology. Med Mycol Case Rep. 2012 Mar 28; 1(1):17-8.

Rücker FG, Schlenk RF, Bullinger L, Kayser S, Teleanu V, Kett H, Habdank M, Kugler CM,  Holzmann K, Gaidzik VI, Paschka P, Held G, von Lilienfeld-Toal M, Lübbert M, Fröhling S, Zenz T, Krauter J, Schlegelberger B, Ganser A, Lichter P, Döhner K, Döhner H. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy  number alterations, monosomal karyotype, and dismal outcome. Blood. 2012 Mar 1;119(9):2114-21. 

Schrödl W, Heydel T, Schwartze VU, Hoffmann K, Walther G, Alastruey-Izquierdo A, Rodriguez-Tudela JL, Olias P, Jacobsen ID, de Hoog GS, Voigt K. Direct analysis and identification of pathogenic Lichtheimia species by matrix-assisted laser desorption ionization-time of flight analyzer-mediated mass spectrometry. J Clin Microbiol. 2012 Feb;50(2):419-27.

Vitale RG, de Hoog GS, Schwarz P, Dannaoui E, Deng S, Machouart M, Voigt K, van de Sande WWJ, Dolatabadi S, Meis JF, Walther G. Antifungal susceptibility and phylogeny of opportunistic members of the order Mucorales. J Clin Microbiol 2012 Jan;50(1):66-75.

Chemnitz JM, von Lilienfeld-Toal M, Holtick U, Theurich S, Shimabukuro-Vornhagen A, Krause A, Brossart P, Hallek M, Scheid C. Intermediate intensity conditioning regimen containing FLAMSA, treosulfan, cyclophosphamide, and ATG for allogeneic stem cell transplantation in elderly patients with relapsed or high-risk acute myeloid leukemia. Ann Hematol. 2012 Jan;91(1):47-55. 

Kayser S, Zucknick M, Döhner K, Krauter J, Köhne CH, Horst HA, Held G, von Lilienfeld-Toal  M, Wilhelm S, Rummel M, Germing U, Götze K, Nachbaur D, Schlegelberger B, Göhring G, Späth D, Morlok C, Teleanu V, Ganser A, Döhner H, Schlenk RF. Monosomal karyotype  in  adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. Blood. 2012 Jan 12;119(2):551-8

Cottier F, Raymond M, Kurzai O, Bolstad M, Leewattanapasuk W, Jiménez-López C, Lorenz MC, Sanglard D, Váchová L, Pavelka N, Palková Z, Mühlschlegel FA. The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast. PLoS Pathog. 2012 Jan; 8(1):e1002485.

Vehreschild MJ, Meissner A, Cornely OA, Maschmeyer G, Neumann S, von Lilienfeld-Toal M, Karthaus M, Wattad M, Staib P, Hellmich M, Christ H, Vehreschild JJ. A clinical definition  for chemotherapy-associated  bowel syndrome predicts severe complications and death in cancer patients. Haematologica. 2011 Dec;96(12):1855-6.

*authors contributed equally